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Shareaza is a file sharing application for Windows that allows you to download and upload music, video etc. on four popular P2P networks: eMule, Gnutella, BitTorrent and Gnutella2. Shareaza is FREE and contains NO spyware or third-party products.

FlashGet is a leading download manager and has the highest amount of users on the internet

Tixati is a bittorrent client featuring detailed views of all seed, peer, and file transfer properties. Also included are bandwidth charting and throttling capabilities, and a DHT implementation.

Deluge is a versatile and easy to use BitTorrent client for Linux, OS X, Unix and Windows.

Transmission is a cross-platform BitTorrent client.

Tomato Torrent is a bitorrent client for Mac OS X.

MLdonkey is a multi-platform, multi-network peer-to-peer client. It supports several large networks such as eDonkey, Overnet, Kademlia, Bittorrent, Gnutella (Bearshare, Limewire, etc.), Gnutella2 (Shareaza), or Fasttrack (Kazaa, Imesh, Grobster). Networks can be enabled or disabled. Searches are performed in parallel on all enabled networks. For some networks, each file can be downloaded from multiple clients concurrently.

BitLord is a p2p file-sharing program compatible with Bittorrent, which is the most popular p2p protocol designed for high-speed distribution of 100MB or GB sized files.