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Shareaza is a file sharing application for Windows that allows you to download and upload music, video etc. on four popular P2P networks: eMule, Gnutella, BitTorrent and Gnutella2. Shareaza is FREE and contains NO spyware or third-party products.

FlashGet is a leading download manager and has the highest amount of users on the internet

Tixati is a bittorrent client featuring detailed views of all seed, peer, and file transfer properties. Also included are bandwidth charting and throttling capabilities, and a DHT implementation.

BitComet is a p2p file-sharing freeware fully compatible with Bittorrent, which is one of the most popular p2p protocol designed for high-speed distribution of 100MB or GB sized files.

Sharepod is an application that allows you to change, backup, and share music, videos, playlists and artwork between a computer and an ipod.

MLdonkey is a multi-platform, multi-network peer-to-peer client. It supports several large networks such as eDonkey, Overnet, Kademlia, Bittorrent, Gnutella (Bearshare, Limewire, etc.), Gnutella2 (Shareaza), or Fasttrack (Kazaa, Imesh, Grobster). Networks can be enabled or disabled. Searches are performed in parallel on all enabled networks. For some networks, each file can be downloaded from multiple clients concurrently.

BitTornado is an alternative the next generation bittorrent client, built on the original BitTorrent, that allows a bit more adjustments than the original client